Engineered Contractile Skeletal Muscle Tissue (Built to Spec)
Aligned, mechanically anchored, electrically stimulable engineered skeletal muscle tissue built and force-tested against a written specification.
| Category | Engineered Contractile Tissue |
|---|---|
| Unit | One engineered muscle construct, or a batch delivered in its casting device |
| Lead time | quote-dependent; expect a multi-week program, not a shipped consumable |
| Pricing | By quotation |
| Provenance | Custom RFQ |
| Data current | 2026-09-01 |
Description
A finished, force-generating skeletal muscle construct: aligned myotubes in an ECM hydrogel, anchored at both ends, matured under electrical stimulation, and delivered against a stated twitch or tetanic force acceptance criterion. This is the single clearest gap in the market. Across roughly thirty organisations surveyed, not one lists a finished, force-specified, mechanically anchored muscle component as a purchasable catalog item. The nearest available things are empty casting plasticware sold to the customer, and fee-for-service research programs that build the tissue internally but deliver a report rather than the object. The physics is not the obstacle: Curi Bio's own published Mantarray validation data reports average twitch forces of roughly 385 to 1,156 uN in iPSC-derived engineered muscle tissues with tetanic forces to about 1,660 uN, and primary human myoblast constructs around 306 uN twitch at day 7 and rising, all on standard 24-well casting plates. Published electrically-stimulated human myobundles have reached 19.3 mN per square millimetre specific force. What does not exist is any party willing to integrate the cell source, the mold, the casting, the stimulation and the force test and hand over the physical part. Wetware World brokers that integration; the tissue itself is manufactured by a named partner and labelled as such.
Why this is hard to buy today
Every component capability exists commercially — cells, molds, casting, stimulation, force testing — but they sit in five or six separate companies and none of them will sell you the assembled physical object, so today the only route is to build an in-house tissue engineering capability.
Price evidence
myriamed lists finished engineered skeletal muscle on a public storefront at EUR 1,400 for one tissue, EUR 5,400 for five and EUR 8,000 for twelve, 7-11 weeks, with a certificate of analysis per batch (live-verified 2026-09-01). It publishes no force acceptance criterion, so it is a catalogue tissue rather than a force-specified component. The do-it-yourself floor remains the empty casting device: eNUVIO OMEGA-MP at USD 440.00 for 4 devices / 8 experiments (live-verified 2026-09-01). Any custom quote should be justified against both numbers.
These are supplier list prices we located and recorded, not a quotation from Wetware World. Your price depends on quantity, specification and freight, and is only binding once issued in writing.
What you must specify
A quote cannot be produced without these. Anything you leave open, a supplier will assume — usually expensively.
| # | Parameter |
|---|---|
| 01 | Tissue length, cross-sectional area and overall geometry |
| 02 | Anchor / termination type at each end (post, loop, clip, suture tab) |
| 03 | Force requirement: twitch and/or tetanic, in micronewtons, with the measurement protocol |
| 04 | Stimulation requirement (frequency range, chronic pacing during maturation, stimulability on delivery) |
| 05 | Cell source (iPSC-derived, primary human, immortalised, rodent) and donor constraints |
| 06 | ECM composition and stiffness |
| 07 | Number of units, and whether a first-article unit precedes the run |
| 08 | Delivery state (live in device, live in transport medium, fixed, or cryopreserved) |
| 09 | Acceptance criteria and what happens to units that fail them |
| 10 | Required functional lifetime after delivery |
Quality documentation
Typically available with this item. What actually ships is confirmed on the quotation, per supplier.
- Contractile force measurement against the stated acceptance criterion (to be negotiated into the contract, not assumed)
- Viability at release
- Myotube alignment and sarcomeric organisation by imaging or histology
- Sterility
- Photographic and dimensional record per unit
Candidate suppliers
Organisations we have identified as capable. Listing does not imply a partnership, an endorsement, or that they have agreed to quote.
| Organisation | Basis for inclusion |
|---|---|
| myriamed | |
| eNUVIO (contract research) | Service list explicitly includes '3D MUSCLE CULTURES // NEUROMUSCULAR JUNCTION MODELS (2D-3D)' and 'NEURAL SPHEROIDS'. States 'we do not offer off-the-shelf assays but rather develop customized assays'. |
| eNUVIO (custom microfabrication) | Advertises design, prototyping and cleanroom production of custom PDMS devices, features in the 1 um range, high aspect ratio molding, glass bonding and surface modification. 'A few custom devices or large batch production.' Quote form only. |
| Curi Bio (Curi Engine services) | Phased fee-for-service: CRISPR iPSC editing 8-16 wk, iPSC expansion/banking 4-6 wk, directed differentiation 4-8 wk, 3D phenotyping study typically 3-5 wk, screening 4-12 wk. Deliverable is a report; whether they will sell the physical tissue is unconfirmed. |
| Creative Biolabs | Advertises Muscle-On-A-Chip Model Development Service providing 'customized, in vitro 3D skeletal muscle models', will use patient cells or CRISPR-engineer mutations, and will tailor device design and culture protocols including mechanical stimulation. Execution quality against a force spec is unproven. |
| Creative Bioarray | Custom 3D cell culture model development including cell patterning for skeletal muscle models. Quote-driven, execution quality unproven. |
| Cook MyoSite | Contract services page lists muscle and adherent cell production, cryopreservation at any scale, procurement from specific donor populations, custom media, and phase-appropriate GMP manufacturing; 3,470 sq ft ISO 7 / ISO 5 cleanroom. No public pricing. |
Sources
- https://enuvio.com/contract-research-services
- https://enuvio.com/custom-microfabricated-devices/
- https://www.curibio.com/curi-engine-services
- https://microfluidics.creative-biolabs.com/muscle-organ-on-a-chip-model.htm
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9445471
- https://www.sciencedirect.com/science/article/pii/S0142961218306185
doc WW-CT-20881 · rev 2026-09-01 · research use only · prices indicative and not binding until quoted in writing